Journal of Pathology and Translational Medicine

Original Articles

BRCA-mutated gastric adenocarcinomas are associated with chromosomal instability and responsiveness to platinum-based chemotherapy: Ji Hyun Oh, Chang Ohk Sung, Hyung-Don Kim, Sung-Min Chun, Jihun Kim; J Pathol Transl Med. 2023;57(6):323-331. Published online November 14, 2023; DOI: https://doi.org/10.4132/jptm.2023.10.22

995 View
180 Download

Abstract PDF Supplementary Material: Background
Homologous recombination defect is an important biomarker of chemotherapy in certain tumor types, and the presence of pathogenic or likely pathogenic mutations involving BRCA1 or BRCA2 (p-BRCA) mutations is the most well-established marker for the homologous recombination defect. Gastric cancer, one of the most prevalent tumor types in Asia, also harbors p-BRCA mutations.
Methods
To investigate the clinical significance of p-BRCA mutations, we analyzed 366 gastric cancer cases through next-generation sequencing. We determined the zygosity of p-BRCA mutations based on the calculated tumor purity through variant allelic fraction patterns and investigated whether the presence of p-BRCA mutations is associated with platinum-based chemotherapy and a certain molecular subtype.
Results
Biallelic p-BRCA mutation was associated with better response to platinum-based chemotherapy than heterozygous p-BRCA mutation or wild type BRCA genes. The biallelic p-BRCA mutations was observed only in the chromosomal instability subtype, while all p-BRCA mutations were heterozygous in microsatellite instability subtype.
Conclusions
In conclusion, patients with gastric cancer harboring biallelic p-BRCA mutations were associated with a good initial response to platinum-based chemotherapy and those tumors were exclusively chromosomal instability subtype. Further investigation for potential association with homologous recombination defect is warranted.

Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time: Miseon Lee, Sung-Min Chun, Chang Ohk Sung, Sun Y. Kim, Tae W. Kim, Se Jin Jang, Jihun Kim; J Pathol Transl Med. 2019;53(6):386-392. Published online October 11, 2019; DOI: https://doi.org/10.4132/jptm.2019.09.25

6,886 View
218 Download
16 Web of Science
14 Crossref

Background
Microsatellite instability (MSI) analysis is becoming increasingly important in many types of tumor including colorectal cancer (CRC). The commonly used MSI tests are either time-consuming or labor-intensive. A fully automated MSI test, the Idylla MSI assay, has recently been introduced. However, its diagnostic performance has not been extensively validated in clinical CRC samples.
Methods
We evaluated 133 samples whose MSI status had been rigorously validated by standard polymerase chain reaction (PCR), clinical nextgeneration sequencing (NGS) cancer panel test, or both. We evaluated the diagnostic performance of the Idylla MSI assay in terms of sensitivity, specificity, and positive and negative predictive values, as well as various sample requirements, such as minimum tumor purity and the quality of paraffin blocks.
Results
Compared with the gold standard results confirmed through both PCR MSI test and NGS, the Idylla MSI assay showed 99.05% accuracy (104/105), 100% sensitivity (11/11), 98.94% specificity (93/94), 91.67% positive predictive value (11/12), and 100% negative predictive value (93/93). In addition, the Idylla MSI assay did not require macro-dissection in most samples and reliably detected MSI-high in samples with approximately 10% tumor purity. The total turnaround time was about 150 minutes and the hands-on time was less than 2 minutes.
Conclusions
The Idylla MSI assay shows good diagnostic performance that is sufficient for its implementation in the clinic to determine the MSI status of at least the CRC samples. In addition, the fully automated procedure requires only a few slices of formalin-fixed paraffin-embedded tissue and might greatly save time and labor.

Citations

Citations to this article as recorded by

Integration of rapid PCR testing as an adjunct to NGS in diagnostic pathology services within the UK: evidence from a case series of non-squamous, non-small cell lung cancer (NSCLC) patients with follow-up
Alison Finall, Gareth Davies, Trevor Jones, Gwion Emlyn, Pearl Huey, Anna Mullard
Journal of Clinical Pathology.2023; 76(6): 391. CrossRef
Analytical Validation and Clinical Utilization of the Oncomine Comprehensive Assay Plus Panel for Comprehensive Genomic Profiling in Solid Tumors
Catherine I. Dumur, Ramakrishnan Krishnan, Jorge A. Almenara, Kathleen E. Brown, Kailyn R. Dugan, Christiana Farni, Fatima Z. Ibrahim, Naomi A. Sanchez, Sumra Rathore, Dinesh Pradhan, Jonathan H. Hughes
Journal of Molecular Pathology.2023; 4(2): 109. CrossRef
Performance of Immunohistochemical and Molecular Methods in Detecting Microsatellite Instability in Gastric Cancer: A Multicenter Study
Diogo Sousa Marques, Irene Gullo, Luís Mascarenhas-Lemos, João Ricardo Silva, Catarina Neto do Nascimento, Patrícia Pontes, Lídia Pinho, Luis Cirnes, Xiaogang Wen, Marília Cravo, Fátima Carneiro
Pathobiology.2023; 90(6): 389. CrossRef
Diagnostic mutationnel rapide Idylla™ : applications théranostiques actuelles et futures
Amélie Bourhis, Annabelle Remoué, Laura Samaison, Arnaud Uguen
Annales de Pathologie.2022; 42(4): 329. CrossRef
Comparison of the Idylla™ MSI assay with the Promega™ MSI Analysis System and immunohistochemistry on formalin-fixed paraffin-embedded tissue of endometrial carcinoma: results from an international, multicenter study
Sonia Gatius, Ana Velasco, Mar Varela, Miriam Cuatrecasas, Pedro Jares, Lisa Setaffy, Benjamin Bonhomme, Almudena Santon, Kristina Lindemann, Sabrina Croce, Ben Davidson, Sigurd Lax, Jose Palacios, Xavier Matias-Guiu
Virchows Archiv.2022; 480(5): 1031. CrossRef
Idylla MSI test combined with immunohistochemistry is a valuable and cost effective strategy to search for microsatellite instable tumors of noncolorectal origin
Laura Samaison, Arnaud Uguen
Pathology International.2022; 72(4): 234. CrossRef
Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA
Adrien Pécriaux, Loetitia Favre, Julien Calderaro, Cécile Charpy, Jonathan Derman, Anaïs Pujals
Journal of Clinical Pathology.2021; 74(1): 36. CrossRef
Idylla microsatellite instability assay versus mismatch repair immunohistochemistry: a retrospective comparison in gastric adenocarcinoma
Luke Farmkiss, Ilona Hopkins, Mary Jones
Journal of Clinical Pathology.2021; 74(9): 604. CrossRef
Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer
Ana Velasco, Fatma Tokat, Jesper Bonde, Nicola Trim, Elisabeth Bauer, Adam Meeney, Wendy de Leng, George Chong, Véronique Dalstein, Lorand L. Kis, Jon A. Lorentzen, Snjezana Tomić, Keeley Thwaites, Martina Putzová, Astrid Birnbaum, Romena Qazi, Vanessa Pr
Virchows Archiv.2021; 478(5): 851. CrossRef
Detection of microsatellite instability with Idylla MSI assay in colorectal and endometrial cancer
Iiris Ukkola, Pirjo Nummela, Annukka Pasanen, Mia Kero, Anna Lepistö, Soili Kytölä, Ralf Bützow, Ari Ristimäki
Virchows Archiv.2021; 479(3): 471. CrossRef
Managing Difficulties of Microsatellite Instability Testing in Endometrial Cancer-Limitations and Advantages of Four Different PCR-Based Approaches
Janna Siemanowski, Birgid Schömig-Markiefka, Theresa Buhl, Anja Haak, Udo Siebolts, Wolfgang Dietmaier, Norbert Arens, Nina Pauly, Beyhan Ataseven, Reinhard Büttner, Sabine Merkelbach-Bruse
Cancers.2021; 13(6): 1268. CrossRef
Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting
Umberto Malapelle, Paola Parente, Francesco Pepe, Caterina De Luca, Pasquale Pisapia, Roberta Sgariglia, Mariantonia Nacchio, Gianluca Gragnano, Gianluca Russo, Floriana Conticelli, Claudio Bellevicine, Elena Vigliar, Antonino Iaccarino, Claudia Covelli,
Cells.2021; 10(8): 1878. CrossRef
Novel Biocartis Idylla™ cartridge-based assay for detection of microsatellite instability in colorectal cancer tissues
Andres E. Mindiola-RomeroMD, Donald C. GreenBS, M. Rabie Al-TurkmaniPhD, Kelley N. GodwinBS, Anna C. MackayBS, Laura J. TafeMD, Bing RenMD, Gregory J. TsongalisPhD
Experimental and Molecular Pathology.2020; 116: 104519. CrossRef
Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers
Pauline Gilson, Julien Levy, Marie Rouyer, Jessica Demange, Marie Husson, Céline Bonnet, Julia Salleron, Agnès Leroux, Jean-Louis Merlin, Alexandre Harlé
Scientific Reports.2020;[Epub] CrossRef

Overexpression of C-reactive Protein as a Poor Prognostic Marker of Resectable Hepatocellular Carcinomas: Jin Ho Shin, Chong Jai Kim, Eun Jeong Jeon, Chang Ohk Sung, Hwa Jeong Shin, Jene Choi, Eunsil Yu; J Pathol Transl Med. 2015;49(2):105-111. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.19

10,591 View
75 Download
20 Web of Science
14 Crossref

Abstract PDF

Background
C-reactive protein (CRP) is an acute phase reactant synthesized in the liver. CRP immunoreactivity is a feature of inflammatory hepatocellular adenomas with a higher risk of malignant transformation. A high serum CRP level denotes poor prognosis in hepatocellular carcinoma (HCC) patients. This study was conducted to determine whether CRP is produced in HCC and to assess the clinicopathologic significance of CRP expression in cancer cells. Methods: CRP immunoreactivity was examined in treatment-naïve HCCs (n=224) using tissue microarrays and was correlated with clinicopathologic parameters. The expression of CRP mRNA and protein was also assessed in 12 HCC cases by quantitative real-time polymerase chain reaction and immunoblotting. Hep3B and SNU-449 HCC cell lines were used for the analysis of CRP mRNA regulation by interleukin 6 (IL-6). Results: CRP was expressed in 133 of 224 HCCs (59.4%) with a variable degree of immunoreactivity (grade 1 in 25.9%; grade 2 in 20.1%; grade 3 in 13.4%). There was an inverse relationship between grade 3 CRP immunoreactivity and cancer-specific survival (p=.0047), while no associations were found with other parameters, including recurrence-free survival. The CRP mRNA expression level was significantly higher in CRP immunopositive cases than in immunonegative cases (p<.05). CRP mRNA expression was increased in Hep3B cells, but was not detected in SNU-449 cells even after IL-6 treatment. Conclusions: We report the expression of CRP in HCC for the first time. CRP expression was associated with poor cancer-specific survival in patients with resectable HCC.

Citations

Citations to this article as recorded by

Peritumoral portal enhancement during transarterial chemoembolization: a potential prognostic factor for patients with hepatocellular carcinoma
Sofi Sennefelt Nyman, Angeliki Dimopoulou Creusen, Ulf Johnsson, Fredrik Rorsman, Johan Vessby, Charlotte Ebeling Barbier
Acta Radiologica.2022; 63(10): 1323. CrossRef
The quest for precision oncology with immune checkpoint inhibitors for hepatocellular carcinoma
Giuseppe Cabibbo, Amit G. Singal
Journal of Hepatology.2022; 76(2): 262. CrossRef
HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas
Pallavi A. Patil, Tamar Taddei, Dhanpat Jain, Xuchen Zhang
Archives of Pathology & Laboratory Medicine.2022; 146(2): 220. CrossRef
Malignant transformation of hepatocellular adenoma
Céline Julien, Brigitte Le Bail, Laurence Chiche, Charles Balabaud, Paulette Bioulac-Sage
JHEP Reports.2022; 4(3): 100430. CrossRef
Effect of Treatment with Colchicine after Acute Coronary Syndrome on Major Cardiovascular Events: A Systematic Review and Meta-Analysis of Clinical Trials
Erfan Razavi, Akam Ramezani, Asma Kazemi, Armin Attar, Baohui Xu
Cardiovascular Therapeutics.2022; 2022: 1. CrossRef
Steatotic and Steatohepatitic Hepatocellular Carcinomas
Umut Aykutlu, Asuman Argon, Mehmet Orman, Sezgin Ulukaya, Murat Zeytunlu, Zeki Karasu, Fulya Günşar, Deniz Nart, Ulus Akarca, Funda Yilmaz
American Journal of Surgical Pathology.2021; 45(9): 1252. CrossRef
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients
Hyuk Soo Eun, Sang Yeon Cho, Byung Seok Lee, Sup Kim, In‐Sang Song, Kwangsik Chun, Cheong‐Hae Oh, Min‐Kyung Yeo, Seok Hyun Kim, Kyung‐Hee Kim
Journal of Gastroenterology and Hepatology.2019; 34(1): 224. CrossRef
Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection
Yoon Ah Cho, Ji Myung Chung, Hyunmi Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Cancer Research and Treatment.2019; 51(3): 1052. CrossRef
Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma
Amit Kumar Ram, Biju Pottakat, Balasubramaniyan Vairappan
BMC Cancer.2018;[Epub] CrossRef
C-reactive Protein Overexpression in the Background Liver of Hepatitis B Virus–Associated Hepatocellular Carcinoma Is a Prognostic Biomarker
Jin Ho Shin, Eunsil Yu, Eun Na Kim, Chong Jai Kim
Journal of Pathology and Translational Medicine.2018; 52(5): 267. CrossRef
Efficacy of vasopressin V2 receptor antagonist tolvaptan in treatment of hepatic edema
Yasunari Hiramine, Hirofumi Uto, Yasushi Imamura, Takuya Hiwaki, Takeshi Kure, Sho Ijuin, Kohei Oda, Seiichi Mawatari, Kotaro Kumagai, Koki Tokunaga, Hirofumi Higashi, Ichiro Kanetsuki, Osamu Kubozono, Shigeho Maenohara, Akio Ido
Hepatology Research.2017; 47(6): 542. CrossRef
Elevated CRP levels predict poor outcome and tumor recurrence in patients with thymic epithelial tumors: A pro- and retrospective analysis
Stefan Janik, Christine Bekos, Philipp Hacker, Thomas Raunegger, Bahil Ghanim, Elisa Einwallner, Lucian Beer, Walter Klepetko, Leonhard Müllauer, Hendrik J. Ankersmit, Bernhard Moser
Oncotarget.2017; 8(29): 47090. CrossRef
Pretreatment neutrophil-to-lymphocyte ratio predicts prognosis in patients with metastatic renal cell carcinoma receiving targeted therapy
Gui-Ming Zhang, Yao Zhu, Wei-Jie Gu, Hai-Liang Zhang, Guo-Hai Shi, Ding-Wei Ye
International Journal of Clinical Oncology.2016; 21(2): 373. CrossRef
Current Proceedings in the Molecular Dissection of Hepatocellular Adenomas: Review and Hands-on Guide for Diagnosis
Diane Goltz, Hans-Peter Fischer
International Journal of Molecular Sciences.2015; 16(9): 20994. CrossRef

Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors: In Hye Song, Joon Seon Song, Chang Ohk Sung, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jeong Hyun Lee, Jung Hwan Baek, Kyung-Ja Cho; J Pathol Transl Med. 2015;49(2):136-143. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.03

10,599 View
185 Download
66 Web of Science
63 Crossref

Abstract PDF

Background
Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

Citations

Citations to this article as recorded by

Giant Pleomorphic Adenoma of Submandibular Gland
Harendra Kumar, Qazi Saquib Rizwan, Mayank Gupta, Tarun Kumar
Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(1): 1361. CrossRef
CT-guided core needle biopsies of head and neck tumors: a comprehensive monocenter analysis of safety and outcomes
Thomas Joseph Vogl, Heinrich Johannes Ketelsen, Scherwin Mahmoudi, Jan-Erik Scholtz, Vitali Koch, Leon David Grünewald, Peter Wild, Timo Stoever, Simon Bernatz
European Radiology.2024;[Epub] CrossRef
Indications for Submandibulectomy Within a 20-Year Period
Amir Bolooki, Anna Stenzl, Christopher Weusthof, Benedikt Hofauer
Ear, Nose & Throat Journal.2024;[Epub] CrossRef
The Usefulness of Ultrasound-Guided Core Needle Biopsy Compared to Fine Needle Aspiration in Pre-Operative Diagnosis of Cystic-Predominant Parotid Tumors
Youn Jin Cho, Young Rok Jo, Hyun Jun Hong, Hye Ran Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(8): 532. CrossRef
The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions
Mohammad Ali Kazemi, Farzaneh Amini, Bita Kargar, Maryam Lotfi, Keyvan Aghazadeh, Hashem Sharifian, Behnaz Moradi, Javid Azadbakht
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 266. CrossRef
Schnellschnittdiagnostik bei Tumoren des Trigonum submandibulare
S. Riemann, A. Knopf
HNO.2023; 71(3): 164. CrossRef
Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report
Georgia Syrnioti, Antonia Syrnioti, Alharith Abdullah, Xuehui Lui, Ernesto Mendoza
Cureus.2023;[Epub] CrossRef
Intraductal Carcinoma: The Carcinoma In Situ of the Salivary Gland
Rhema Thomas, Tijjani Umar, Farzad Borumandi
Journal of Craniofacial Surgery.2023; 34(5): e432. CrossRef
Fine-Needle Aspiration Cytology for Parotid Tumors
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Life.2022; 12(11): 1897. CrossRef
Utility of the Milan System for Reporting Salivary Gland Cytology, with focus on the incidence and histologic correlates of atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP): A 3‐year institution
Christopher M. Cormier, Shweta Agarwal
Cancer Cytopathology.2022; 130(4): 303. CrossRef
Percutaneous CT-Guided Core Needle Biopsies of Head and Neck Masses: Review of 184 Cases at a Single Academic Institution, Common and Special Techniques, Diagnostic Yield, and Safety
R.W. Jordan, D.P. Shlapak, J.C. Benson, F.E. Diehn, D.K. Kim, V.T. Lehman, G.B. Liebo, A.A. Madhavan, J.M. Morris, P.P. Morris, J.T. Verdoorn, C.M. Carr
American Journal of Neuroradiology.2022; 43(1): 117. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Validation of the Milan system for reporting salivary gland cytopathology: a single institution’s 10-year experience
Christopher Felicelli, Joseph Reznicek, Yevgen Chornenkyy, Lucy Jager, Daniel Johnson
Journal of the American Society of Cytopathology.2022; 11(5): 264. CrossRef
Application of the Milan system for reporting salivary gland cytopathology using cell blocks
Grégoire B. Morand, Raihanah Alsayegh, Alex M. Mlynarek, Marianne Plourde, Tiffany Mach, Marco A. Mascarella, Michael P. Hier, Livia Florianova, Marc P. Pusztaszeri
Virchows Archiv.2022; 481(4): 575. CrossRef
Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors
Ping-Chia Cheng, Wu-Chia Lo, Chih-Ming Chang, Ming-Hsun Wen, Po-Wen Cheng, Li-Jen Liao
Diagnostics.2022; 12(10): 2488. CrossRef
A Novel Sonographic Scoring Model in the Prediction of Major Salivary Gland Tumors
Wu‐Chia Lo, Chih‐Ming Chang, Chi‐Te Wang, Po‐Wen Cheng, Li‐Jen Liao
The Laryngoscope.2021;[Epub] CrossRef
Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study
Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, Khurram Shafique, Sharon Song, Kartik Viswanathan, Elizabeth Eykman, Rema A. Rao, Austin Wiles, Güliz A. Barkan, Ritu Nayar, Guido Fadda, Celeste N. Powers, Esther Diana Rossi, Momin T. S
Cancer Cytopathology.2021; 129(1): 43. CrossRef
Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation
Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
European Journal of Radiology.2021; 139: 109716. CrossRef
The Milan System, from Its Introduction to Its Current Adoption in the Diagnosis of Salivary Gland Cytology
Esther Diana Rossi
Journal of Molecular Pathology.2021; 2(2): 114. CrossRef
Utility of the Milan system for reporting salivary gland cytopathology during rapid on‐site evaluation (ROSE) of salivary gland aspirates
Aanchal Kakkar, Mukin Kumar, Priyadarsani Subramanian, Arshad Zubair, Rajeev Kumar, Alok Thakar, Deepali Jain, Sandeep R. Mathur, Venkateswaran K. Iyer
Cytopathology.2021; 32(6): 779. CrossRef
Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
Tolga Bağlan, Serpil Dizbay Sak, Cevriye Cansız Ersöz, Koray Ceyhan
Diagnostic Cytopathology.2021; 49(4): 509. CrossRef
Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
Swati P. Satturwar, Maren Y. Fuller, Sara E. Monaco
Cancer Cytopathology.2021; 129(11): 884. CrossRef
Radiographic Interpretation in Oral Medicine and Hospital Dental Practice
Katherine France, Anwar A.A.Y. AlMuzaini, Mel Mupparapu
Dental Clinics of North America.2021; 65(3): 509. CrossRef
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings
Can Wang, Qiang Yu, Siyi Li, Jingjing Sun, Ling Zhu, Pingzhong Wang
Dentomaxillofacial Radiology.2021; 50(7): 20200485. CrossRef
Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations
Aurore Surun, Dominik T. Schneider, Andrea Ferrari, Teresa Stachowicz‐Stencel, Jelena Rascon, Anna Synakiewicz, Abbas Agaimy, Kata Martinova, Denis Kachanov, Jelena Roganovic, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Frédéric Kolb, Juliette Thariat, Anto
Pediatric Blood & Cancer.2021;[Epub] CrossRef
A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology
Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
The Laryngoscope.2020; 130(1): 80. CrossRef
Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Liliya Benchetrit, Sina J. Torabi, Elliot Morse, Saral Mehra, Rahmatullah Rahmati, Heather A. Osborn, Benjamin L. Judson
The Laryngoscope.2020; 130(6): 1450. CrossRef
α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients
Sireesha Manne, Naveen Kondru, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy
Movement Disorders.2020; 35(2): 268. CrossRef
The Accessory Parotid Gland and its Clinical Significance
Mateusz A. Rosa, Dominik P. Łazarz, Jakub R. Pękala, Bendik Skinningsrud, Sigurd S. Lauritzen, Bernard Solewski, Przemysław A. Pękala, Jerzy A. Walocha, Krzysztof A. Tomaszewski
Journal of Craniofacial Surgery.2020; 31(3): 856. CrossRef
Comparison of core needle biopsy and fine‐needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta‐analysis
Jungheum Cho, Junghoon Kim, Ji Sung Lee, Choong Guen Chee, Youngjune Kim, Sang Il Choi
Head & Neck.2020; 42(10): 3041. CrossRef
The Milan system for reporting salivary gland cytopathology: The clinical impact so far. Considerations from theory to practice
Esther Diana Rossi, William C. Faquin
Cytopathology.2020; 31(3): 181. CrossRef
The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration
Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
American Journal of Otolaryngology.2020; 41(6): 102718. CrossRef
Role of Fine Needle Aspiration Cytology in the Diagnosis of Parotid Gland Tumors: Analysis of 193 Cases
Rahim Dhanani, Haissan Iftikhar, Muhammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin
International Archives of Otorhinolaryngology.2020; 24(04): e508. CrossRef
Cytohistological correlation of salivary gland tumours with emphasis on Milan system for reporting: A novel step towards internal quality assurance
Anandraj Vaithy.K, ATM Venkat Raghava, E S Keerthika Sri, K R Umadevi
IP Archives of Cytology and Histopathology Research.2020; 5(4): 283. CrossRef
Diagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary Studies
Esther Diana Rossi, Zubair Baloch, William Faquin, Liron Pantanowitz
AJSP: Reviews and Reports.2020; 25(5): 210. CrossRef
Peripheral T Cell Lymphoma of Parotid Gland: A Diagnostic Challenge
J. G. Aishwarya, Satish Nair, C. N. Patil, Swarna Shivakumar, N. Shrivalli, Ashish Shah
Indian Journal of Otolaryngology and Head & Neck Surgery.2019; 71(S1): 533. CrossRef
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis
Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
Modern Rheumatology.2019; 29(2): 393. CrossRef
Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature
Sahar J Farahani, Zubair Baloch
Diagnostic Cytopathology.2019; 47(2): 67. CrossRef
Values of fine‐needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution
Manabu Suzuki, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin‐Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
Head & Neck.2019; 41(2): 358. CrossRef
Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
Liliya Benchetrit, Elliot Morse, Benjamin L. Judson, Saral Mehra
Otolaryngology–Head and Neck Surgery.2019; 161(4): 620. CrossRef
The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor
Jungirl Seok, Woo-Jin Jeong, Soon-Hyun Ahn, Young Ho Jung
European Archives of Oto-Rhino-Laryngology.2019; 276(7): 2091. CrossRef
The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma
Jungirl Seok, Se Jin Hyun, Woo-Jin Jeong, Soon-Hyun Ahn, Hyojin Kim, Young Ho Jung
Ear, Nose & Throat Journal.2019; 98(8): 504. CrossRef
Fine‐needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients
Clare Perkins, Edward Toll, Philip Reece
Clinical Otolaryngology.2019; 44(6): 1124. CrossRef
Ultrasound‐guided core needle biopsy in salivary glands: A meta‐analysis
Hee Joon Kim, Jong Seung Kim
The Laryngoscope.2018; 128(1): 118. CrossRef
Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands
Jose Luis del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
European Radiology.2018; 28(7): 2934. CrossRef
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC–sponsored system for reporting salivary gland fine-needle aspiration
Esther Diana Rossi, Zubair Baloch, Marc Pusztaszeri, William C. Faquin
Journal of the American Society of Cytopathology.2018; 7(3): 111. CrossRef
Routine and Advanced Ultrasound of Major Salivary Glands
Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
Neuroimaging Clinics of North America.2018; 28(2): 273. CrossRef
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An ASC-IAC-Sponsored System for Reporting Salivary Gland Fine-Needle Aspiration
Esther Diana Rossi, Zubair W. Baloch, Marc Pusztaszeri, William C. Faquin
Acta Cytologica.2018; 62(3): 157. CrossRef
Evaluation and diagnosis of salivary gland neoplasms
Erica Jackson Mayland, Anna M. Pou
Operative Techniques in Otolaryngology-Head and Neck Surgery.2018; 29(3): 129. CrossRef
Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S. Coffey, Michael Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, V
Journal of Parkinson's Disease.2018; 8(4): 517. CrossRef
Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?
Peter Zbären, Asterios Triantafyllou, Kenneth O. Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2609. CrossRef
A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?
Diana Montezuma, Sule Canberk, Ozlem Aydın, Mehmet Polat Dermirhas, André F. Vieira, Süha Goksel, Ümit İnce, Fernando Schmitt
Diagnostic Cytopathology.2018; 46(10): 859. CrossRef
Pediatric salivary gland carcinomas: Diagnostic and therapeutic management
Céleste Rebours, Vincent Couloigner, Louise Galmiche, Odile Casiraghi, Cécile Badoual, Sabah Boudjemaa, Anthony Chauvin, Monique Elmaleh, Brice Fresneau, Sylvie Fasola, Erea‐Noël Garabédian, Thierry Van Den Abeele, Daniel Orbach
The Laryngoscope.2017; 127(1): 140. CrossRef
Agreement between rapid on‐site evaluation and the final cytological diagnosis of salivary gland specimens
S. Wangsiricharoen, S. Lekawanvijit, S. Rangdaeng
Cytopathology.2017; 28(4): 321. CrossRef
Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration
James Lee, Samia Kazmi, Christopher J. VandenBussche, Syed Z. Ali
Journal of the American Society of Cytopathology.2017; 6(3): 105. CrossRef
Clinical Results of Surgical Treatment in Parotid Tumors
Ahmet Kara
Journal of Otolaryngology-ENT Research.2017;[Epub] CrossRef
Parotid gland metastases of distant primary tumours: A diagnostic challenge
Achim M. Franzen, Thomas Günzel, Anja Lieder
Auris Nasus Larynx.2016; 43(2): 187. CrossRef
Modern Radiology in the Management of Head and Neck Cancer
G.J.C. Burkill, R.M. Evans, V.V. Raman, S.E.J. Connor
Clinical Oncology.2016; 28(7): 440. CrossRef
Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Paul A. VanderLaan
Cancer Cytopathology.2016; 124(12): 862. CrossRef
Staging and follow-up of high-grade malignant salivary gland tumours: The role of traditional versus functional imaging approaches – A review
Nicole Freling, Flavio Crippa, Roberto Maroldi
Oral Oncology.2016; 60: 157. CrossRef
Biopsy of parotid masses: Review of current techniques
Sananda Haldar, Joseph D Sinnott, Kemal M Tekeli, Samuel S Turner, David C Howlett
World Journal of Radiology.2016; 8(5): 501. CrossRef
Review on the applications of ultrasonography in dentomaxillofacial region
Şehrazat Evirgen
World Journal of Radiology.2016; 8(1): 50. CrossRef
Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma
Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
Journal of Pathology and Translational Medicine.2015; 49(6): 511. CrossRef

Brief Case Reports

Mixed Carcinoid-Mucinous Adenocarcinoma Arising in Mature Teratoma of Mesentery: Su-Jin Shin, Eun-Mi Son, Chang Ohk Sung, Kyu-Rae Kim; J Pathol Transl Med. 2015;49(1):61-65. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.09.17

9,986 View
81 Download
3 Web of Science
3 Crossref

PDF

Citations

Citations to this article as recorded by

Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma
Sandhyarani Dasaraju, Khalid Amin, Molly E. Klein, Colleen Rivard, Jordan Mattson, Sarah Davidson, Mahmoud A. Khalifa
Gynecologic Oncology Reports.2022; 44: 101099. CrossRef
A Case of Mature Cystic Teratoma of the Mesentery
Ryogo Ito, Motoi Yoshihara, Atsuki Arimoto, Taro Aoba, Yoshihisa Shibata, Kazuhiro Hiramatsu, Takehito Kato
The Japanese Journal of Gastroenterological Surgery.2021; 54(5): 344. CrossRef
Primary ovarian mixed strumal and mucinous carcinoid arising in an ovarian mature cystic teratoma
Na Rae Kim, Seung Yeon Ha, Jin Woo Shin, Soyi Lim, Chan Yong Park, Hyun Yee Cho
Journal of Obstetrics and Gynaecology Research.2016; 42(2): 211. CrossRef

Peritoneal Carcinosarcoma and Ovarian Papillary Serous Carcinoma Are the Same Origin: Analysis of TP53 Mutation and Microsatellite Suggests a Monoclonal Origin: Chang Gok Woo, Dae Shik Suh, Joo Young Kim, Chang Ohk Sung, Jene Choi, Kyu-Rae Kim; Korean J Pathol. 2014;48(6):449-453. Published online December 31, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.449

11,617 View
48 Download
3 Crossref

PDF

Citations

Citations to this article as recorded by

A successfully treated primary peritoneal carcinosarcoma and serous carcinoma of stage IIIC rescued from hypovolemic shock due to tumor rupture
Che-Cheng Huang, Horng-Jyh Tsai, Shih Hsuan Huang, Victor C. Kok
Taiwanese Journal of Obstetrics and Gynecology.2019; 58(2): 296. CrossRef
Ovarian Carcinosarcoma and Concurrent Serous Tubal Intraepithelial Carcinoma With Next-Generation Sequencing Suggesting an Origin From the Fallopian Tube
Sharlene Helene C. See, Amir Behdad, Kruti P. Maniar, Luis Z. Blanco
International Journal of Surgical Pathology.2019; 27(5): 574. CrossRef
Progression inference for somatic mutations in cancer
Leif E. Peterson, Tatiana Kovyrshina
Heliyon.2017; 3(4): e00277. CrossRef

Original Article

Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors: Soomin Ahn, Jae Jun Lee, Sang Yun Ha, Chang Ohk Sung, Jhingook Kim, Joungho Han; Korean J Pathol. 2012;46(3):221-225. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.221

8,315 View
74 Download
28 Crossref

Abstract PDF

Background

Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.

Methods

We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.

Results

It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.

Conclusions

In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

Citations

Citations to this article as recorded by

Thymic neuroendocrine tumours
Jan von der Thüsen
Diagnostic Histopathology.2023; 29(2): 114. CrossRef
The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions
Uma Kundu, Qiong Gan, Deepak Donthi, Nour Sneige
Diagnostics.2023; 13(14): 2400. CrossRef
Paediatric and adolescent ectopic Cushing's syndrome: systematic review
Chethan Yami Channaiah, Manjiri Karlekar, Vijaya Sarathi, Anurag Ranjan Lila, Shruthi Ravindra, Padma Vikram Badhe, Gaurav Malhotra, Saba Samad Memon, Virendra Ashokrao Patil, C S Pramesh, Tushar Bandgar
European Journal of Endocrinology.2023; 189(4): S75. CrossRef
Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)
Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen
Seminars in Cancer Biology.2022; 79: 141. CrossRef
Multiple electrolyte disturbances as the presenting feature of multiple endocrine neoplasia type 1 (MEN-1)
Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E Drakou, Royce P Vincent, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
Endocrinology, Diabetes & Metabolism Case Reports.2022;[Epub] CrossRef
Metastatic Thymic Carcinoid: Does Surgeon Have a Primary Role?
Kumud Gupta, Ravindra K. Dewan, Vinitha Viswambharan Nair, Rajat Saxena, Shaleen Prasad
The Indian Journal of Chest Diseases and Allied Sciences.2022; 56(4): 255. CrossRef
A resected case of large cell neuroendocrine carcinoma of the thymus
Masashi Umeda, Takahiko Misao, Tomoya Senoh, Yoshinobu Shikatani, Motoi Aoe
The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 766. CrossRef
Treatment strategy and prognostic analysis of spinal metastases from thymomas: A retrospective study from a single center
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, Siyuan Yao, Yipeng Wang, Yong Liu
Clinical Neurology and Neurosurgery.2020; 196: 106056. CrossRef
Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy
Takeaki Hidaka, Saki Okuzumi, Ako Matsuhashi, Hidenori Takahashi, Kazunori Hata, Seiichiro Shimizu, Yoshinobu Iwasaki
Internal Medicine.2019; 58(4): 563. CrossRef
Surgical management of spinal metastases of thymic carcinoma
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
Medicine.2019; 98(3): e14198. CrossRef
Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature
Shogo Ogata, Ryo Maeda, Masaki Tomita, Yuichiro Sato, Takanori Ayabe, Kunihide Nakamura
International Journal of Surgery Case Reports.2019; 60: 53. CrossRef
Metastatic or locally advanced mediastinal neuroendocrine tumours
Aadil Adnan, Shreyas Kudachi, Sudha Ramesh, Kumar Prabhash, Sandip Basu
Nuclear Medicine Communications.2019; 40(9): 947. CrossRef
Results of treatment for thymic neuroendocrine tumours: multicentre clinicopathological study†
Naoko Ose, Hajime Maeda, Masayoshi Inoue, Eiichi Morii, Yasushi Shintani, Hiroshi Matsui, Hirohito Tada, Tositeru Tokunaga, Kenji Kimura, Yasushi Sakamaki, Yukiyasu Takeuchi, Kenjiro Fukuhara, Hiroshi Katsura, Teruo Iwasaki, Meinoshin Okumura
Interactive CardioVascular and Thoracic Surgery.2018; 26(1): 18. CrossRef
Patterns of Failure Following Postoperative Radiation Therapy Based on “Tumor Bed With Margin” for Stage II to IV Type C Thymic Epithelial Tumor
Kyung Hwa Lee, Jae Myoung Noh, Yong Chan Ahn, Dongryul Oh, Jhingook Kim, Young Mog Shim, Jung-ho Han
International Journal of Radiation Oncology*Biology*Physics.2018; 102(5): 1505. CrossRef
Resected thymic large cell neuroendocrine carcinoma: report of a case
Hiromitsu Domen, Yasuhiro Hida, Masaaki Sato, Haruka Takahashi, Tatsuru Ishikawa, Yosuke Shionoya, Midori Hashimoto, Kaoru Nishiyama, Yuma Aoki, Kazuho Inoko, Syotaro Furukawa, Kazuomi Ichinokawa, Hidehisa Yamada
Surgical Case Reports.2018;[Epub] CrossRef
Successful treatment of malignant thymoma with sacrum metastases
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
Medicine.2018; 97(51): e13796. CrossRef
Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report
Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
Journal of Medical Case Reports.2017;[Epub] CrossRef
Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift
Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Paolo Bidoli, Stefania Canova, Diego Cortinovis, Maria Ida Abbate, Fiorella Calabrese, Nazarena Nannini, Francesca Lunardi, Giulio Rossi, Stefano La Rosa, Carlo Capella, Elena Tamborini, Federica Perrone,
Virchows Archiv.2017; 471(1): 31. CrossRef
Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report
Efared Boubacar, Gabrielle Atsame-Ebang, Sani Rabiou, Ammor Fatimazahra, Asmae Mazti, Ibrahim S. Sidibé, Layla Tahiri, Nawal Hammas, Ouadnouni Yassine, Smahi Mohamed, Chbani Laila, El Fatemi Hinde
Journal of Medical Case Reports.2017;[Epub] CrossRef
Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver
Yoriko Nomura, Osamu Nakashima, Jun Akiba, Sachiko Ogasawara, Shogo Fukutomi, Rin Yamaguchi, Hironori Kusano, Masayoshi Kage, Koji Okuda, Hirohisa Yano
Journal of Clinical Pathology.2017; 70(7): 563. CrossRef
Retrosternal goiter and thymic carcinoid: A rare co-existence
Abdulsalam Yaseen Taha, Nezar A. Almahfooz, Hassanain H. Khudair
Journal of the Egyptian Society of Cardio-Thoracic Surgery.2017; 25(4): 369. CrossRef
A case of large-cell neuroendocrine carcinoma of the thymus involving a patient with long-term survival after surgery
Qiuming Kan, Kohei Tagawa, Teruaki Ishida, Mitsuyo Nishimura, Katsuhiko Aoyama
The Journal of the Japanese Association for Chest Surgery.2017; 31(7): 927. CrossRef
Neuroendokrine Neoplasien des Mediastinums
L. Brcic, M. Heidinger, H. Popper
Der Pathologe.2016; 37(5): 434. CrossRef
Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Pier Luigi Filosso, Xiaopan Yao, Usman Ahmad, Yilei Zhan, James Huang, Enrico Ruffini, William Travis, Marco Lucchi, Andreas Rimner, Alberto Antonicelli, Francesco Guerrera, Frank Detterbeck
The Journal of Thoracic and Cardiovascular Surgery.2015; 149(1): 103. CrossRef
Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
Young Bae Choi, Go Eun Bae, Na Hee Lee, Jung-Sun Kim, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Journal of Korean Medical Science.2015; 30(8): 1062. CrossRef
Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi‐institutional clinicopathologic study
Philipp Ströbel, Andreas Zettl, Konstantin Shilo, Wen‐Yu Chuang, Andrew G. Nicholson, Yoshihiro Matsuno, Anthony Gal, Rolf Hubert Laeng, Peter Engel, Carlo Capella, Mirella Marino, John Kwok-Cheung Chan, Andreas Rosenwald, William Travis, Teri J. Franks,
Genes, Chromosomes and Cancer.2014; 53(9): 738. CrossRef
Disseminated large cell neuroendocrine carcinoma associated with ectopic adrenocorticotropic hormone secretion
A Van der Walt, K Huddle, S Pather, A Korb
Journal of Endocrinology, Metabolism and Diabetes of South Africa.2014; 19(1): 40. CrossRef
Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
Korean Journal of Pathology.2013; 47(5): 433. CrossRef

Case Report

Mucinous Bronchioloalveolar Carcinoma Associated with Bronchiectatic Cyst: A Brief Case Report.: Chang Ohk Sung, Joungho Han, Sang Won Um, Chin A Yi, Young Mog Shim; Korean J Pathol. 2010;44(5):540-542.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.540

2,770 View
16 Download

Abstract PDF: Herein we report a rare case of mucinous bronchioloalveolar carcinoma (BAC) associated with a solitary bronchiectatic cyst in a 29-year-old man. The patient presented with hemoptysis and had a history of pulmonary tuberculosis. Chest radiographs and computed tomography revealed a well-circumscribed, thin-walled cavitary lesion in the right upper pulmonary lobe. Gross examination of a lobectomy specimen showed a bronchiectatic cavity and a fungus ball within it. There were also several ill-defined small gray-white nodules around the cyst, nodules that were mucinous BAC. On microscopy, they were composed of columnar tumor cells along the intact alveolar walls in a single layer.

Short Case Report

Squamous Cell Carcinoma Arising in a Thymic Cyst : A Brief Case Report.: Chang Ohk Sung, Joungho Han, Ji Yeon Kim, Young Mog Shim, Tae Sung Kim; Korean J Pathol. 2009;43(3):260-262.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.260

3,186 View
18 Download
1 Crossref

Abstract PDF

We present here the case of a 73-year-old man with squamous cell carcinoma that arose in a thymic cyst, and this was incidentally found by chest radiography. Computed tomography revealed a 3.6 cm-sized predominantly cystic lesion with a mural nodule at the antero-superior mediastinum. The resected specimen was a well demarcated cystic mass with a solid mural nodule. Microscopically, the nodule was determined to be invasive squamous cell carcinoma that had originated from the benign squamous epithelium lining the thymic cyst.

Citations

Citations to this article as recorded by

Multilocular Thymic Cyst with Prominent Lymphoid Follicular Hyperplasia: A Case Report
Na-Ra Yoon, Ji Yun Jeong, Joungho Han, Jhingook Kim, Chin A Yi
Journal of Lung Cancer.2012; 11(1): 45. CrossRef

Original Article

Clinicopathologic Features of Early Hepatocellular Carcinoma.: Chang Ohk Sung, Suk Jin Choi, Cheol Keun Park; Korean J Pathol. 2004;38(3):138-144.

1,777 View
16 Download

Abstract PDF: BACKGROUND
Early hepatocellular carcinoma (HCC) is an early stage HCC, and it is sometimes difficult to identify the margins of the cancer nodules in the resected specimens.
METHODS
We studied 22 cases of early HCC to investigate the clinicopathologic features of early stage HCC.
RESULTS
Seven of 22 cases were single HCC, and 15 were multicentric HCC. The average tumor size was 1.34 cm (0.4-2.7 cm). Early HCCs didn't destroy the basic architecture of the liver lobules or pseudolobules and the lesions had an indistinct margin. Most tumors were uniformly composed of well-differentiated cancer tissue that was characterized by an increased cell density and an irregular thin-trabecular pattern. The tumor retained a varying number of portal tracts. There was a replacing growth pattern at the tumor-nontumor boundary without tumor capsule. Three of 22 cases had a "nodule-in-nodule" lesion, and the inner nodules consisted of moderately differentiated HCC without portal tracts. All 22 cases showed no vascular invasion. All 7 patients with single early HCC have survived for the past 11-54 months without any local recurrence. But in one patient with single early HCC, multicentric HCC developed 20 months after surgery.
CONCLUSION
The clinicopathologic features of early HCCs are quite different from those of advanced HCCs. The increased recognition of early HCC during routine clinical practice will contribute to improved patient survival.

Case Report

Giant Multilocular Cystadenoma of the Prostate: A Case Report.: Chang Ohk Sung, Jinwon Seo, Sang Yong Song; Korean J Pathol. 2004;38(2):106-108.

1,583 View
20 Download

Abstract PDF: Large multilocular cysts and cystic neoplasms of the prostate are very rare. A healthy 52-year-old man presented with acute urinary retension. Physical examination revealed a large abdominal mass. Pelvic MRI showed a 15x10x9 cm, lobulated, and multiseptated cystic mass in the pelvic cavity. Exploration laparotomy revealed a large cytic mass that compressd and displaced the urinary bladder antero-laterally, and adhered to the prostate and the sigmoid colon. Macroscopically, the mass was grayish white colored, multilocular cysts containing reddish-brown serous fluid. Microscopically, the tumor was composed of glands and cysts lined by the prostatic-type epithelium in the fibrous stroma. The prostatic nature of the lesion was confirmed by the lining epithelium expressing prostate-specific antigen.

First
Prev
Page of 1
Next
Last

Search